Bcl-2 binds to and inhibits ryanodine receptors
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منابع مشابه
Bcl - 2 binds to and inhibits ryanodine receptors 1
Tim Vervliet, Elke Decrock, Jordi Molgó, Vincenzo Sorrentino, Ludwig Missiaen, Luc 2 Leybaert, Humbert De Smedt, Nael Nadif Kasri, Jan B. Parys, Geert Bultynck 3 4 Affiliations 5 1 KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and 6 Molecular Medicine, B-3000 Leuven, Belgium 7 2 University of Ghent, Physiology Group, Department Basic Medical Sciences, B-9000 ...
متن کاملBcl-2 binds to and inhibits ryanodine receptors.
The anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein not only counteracts apoptosis at the mitochondria by scaffolding pro-apoptotic Bcl-2-family members, but also acts at the endoplasmic reticulum, thereby controlling intracellular Ca(2+) dynamics. Bcl-2 inhibits Ca(2+) release by targeting the inositol 1,4,5-trisphosphate receptor (IP3R). Sequence analysis has revealed that the Bcl-2-binding ...
متن کاملCytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL.
Humanin (HN) is a recently identified endogenous peptide that protects cells against cytotoxicity induced by various stimuli. Recently, we showed that HN binds to and inhibits Bax, a proapoptotic Bcl-2 family protein, suggesting a mechanism for HN action. In this study, we identified Bim, a Bcl-2 homology 3-only member of the Bcl-2/Bax family, as an additional HN target protein. Using in vitro ...
متن کاملThe block of ryanodine receptors selectively inhibits fetal myoblast differentiation.
Differentiation and morphogenesis of skeletal muscle are complex and asynchronous events that involve various myogenic cell populations and extracellular signals. Embryonic and fetal skeletal myoblasts are responsible for the formation of primary and secondary fibers, respectively, although the mechanism that diversifies their fate is not fully understood. Calcium transients appear to be a sign...
متن کاملRyanodine receptors
ISSN: 1933-6950 (Print) 1933-6969 (Online) Journal homepage: http://www.tandfonline.com/loi/kchl20 Ryanodine receptors Mounia Chami & Frédéric Checler To cite this article: Mounia Chami & Frédéric Checler (2014) Ryanodine receptors, Channels, 8:3, 168-168, DOI: 10.4161/chan.29000 To link to this article: http://dx.doi.org/10.4161/chan.29000 Copyright © 2014 Landes Bioscience Published online: 2...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2014
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.150011